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Dr. Susan Cutler discussing xerostomia and the benefits of NeutraSal®.

See how NeutraSal® works.

 

Frequently asked questions


What are the indications for NeutraSal®?

NeutraSal® is indicated for:

  • dryness of the mouth (hyposalivation, xerostomia)
  • dryness of the oral mucosa due to drugs such as antihistamines or atropine or other anticholinergic agents that suppress salivary secretion
  • use as part of an oral hygiene program for patients with dry mouth
  • providing intensive hygiene of the oral cavity
  • use as an adjunct to standard oral care in relieving the discomfort associated with oral mucositis that may be caused by radiation or high-dose chemotherapy
  • relief of dryness of the oral mucosa in these conditions is associated with amelioration of pain

NeutraSal® may be used for relief of dryness of the oral mucosa when hyposalivation results from the following:

  • surgery
  • chemotherapy
  • radiotherapy near the salivary glands
  • infection or dysfunction of the salivary glands
  • obstruction of the salivary ducts
  • fever
  • emotional factors such as fear or anxiety
  • Sjögren's syndrome

What are the ingredients in NeutraSal®?

(Active) Dibasic Sodium Phosphate, Monobasic Sodium Phosphate, Calcium Glycerophosphate, Sodium Chloride, Sodium Bicarbonate (Inactive) Silicon dioxide

Does NeutraSal® have any potential allergens, like wheat or nuts?

NeutraSal® has no wheat, nuts, eggs, gluten, yeast, milk, soy, shellfish, or preservative ingredients. There have been no reported allergic reactions, but it is not impossible that one could occur.

What is the safety profile of NeutraSal®?

NeutraSal® has an established safety profile:

  • Not intended to prevent xerostomia or oral mucositis.
  • Patients should avoid eating or drinking for at least 15 minutes after use
  • Solution should not be swallowed but be spit out.
  • Not intended for systemic use to treat any diseases of the throat or upper gastrointestinal tract
  • Not intended for use as an antacid
  • No adverse events anticipated if swallowed accidentally
  • Contains sodium; consult with patients on a low sodium diet
  • No known interactions with medicinal or other products

Please click here for Instructions for Use.

What are the recommended dosages of NeutraSal®?

Is it acceptable to mix NeutraSal® in more than 1 ounce (30 mL) of water, for example, a full glass of drinking water (6-8 oz)?

NeutraSal® must be diluted in 1 ounce of water to achieve the full clinical benefit.

How does NeutraSal® taste?

NeutraSal® has a slightly salty taste; however, it is well tolerated by patients.

Is there a benefit to NeutraSal® delivery as a powder to be mixed at the time of use vs a liquid delivery system?

The present formulation can provide higher concentrations of calcium and phosphate, a difference made possible by providing a stable powder to be mixed with water, in contrast to commercially available liquid products. The delivery through a powder allows for the creation of an oral rinse that achieves statistically significantly higher levels of calcium and phosphate than can otherwise be achieved when delivered in liquid containing calcium and phosphate.1 NeutraSal® is a supersaturated solution of calcium phosphate.

Why does NeutraSal® have to be used within 15 seconds after mixing? Can it be pre-mixed in the morning and used later in the day?

NeutraSal® should be used within 15 seconds after mixing to achieve the full clinical benefit. After this time period, the supersaturation benefit of the calcium phosphate ions will decrease. Calcium phosphate dissolves in water to form a supersaturated solution, but the supersaturated solution is not stable and calcium phosphate could precipitate out if the supersaturated solution sits for a long time. Multiple factors, such as changing temperature, increasing pressure, etc, could cause precipitation from a supersaturated solution.

How does NeutraSal® improve the oral environment?

It is an advanced electrolyte solution that mimics natural saliva and contains electrolytes such as calcium, phosphate, sodium, bicarbonate, and chloride, which are necessary for a healthy, functioning mouth. NeutraSal® is designed to replace the normal ionic and pH balance in the mouth.

When NeutraSal® is taken, ions in the the mouth such as calcium and phosphate play crucial roles in the protection process and aid in mineralization. Bicarbonate reduces the acidity (raises pH) of oral fluids.

Does NeutraSal® cure xerostomia and oral mucositis?

No, NeutraSal® mimics natural saliva and helps alleviate symptoms of xerostomia and oral mucositis while helping to protect oral mucosal tissues. Please see your dentist or healthcare provider for more information.

Is NeutraSal® an anticavity rinse?

NeutraSal® is not indicated as an anticavity rinse. It is indicated for the treatment of xerostomia and oral mucositis. However, by mimicking saliva, the calcium and phosphate help mineralize enamel and the bicarbonate raises the pH of the oral cavity.

INDICATIONS

NeutraSal® is indicated for dryness of the mouth (hyposalivation, xerostomia) and dryness of the oral mucosa due to drugs that suppress salivary secretion.

IMPORTANT SAFETY INFORMATION

  • Not intended to prevent xerostomia or oral mucositis.
  • Patients should avoid eating or drinking for at least 15 minutes after use
  • Solution should not be swallowed but be spit out.
  • Not intended for systemic use to treat any diseases of the throat or upper gastrointestinal tract
  • Not intended for use as an antacid
  • No adverse events anticipated if swallowed accidentally
  • Contains sodium; consult with patients on a low sodium diet
  • No known interactions with medicinal or other products

Please click here for Instructions for Use.

1. Singh ML, Papas AS. Long-term clinical observation of dental caries in salivary hypofunction patients using a supersaturated calcium phosphate mineralizing rinse. J Clin Dent. 2009;20(3):87-92.

*Terms and Conditions: This offer is only valid for patients with commercial insurance where NeutraSal® (Supersaturated Calcium Phosphate Rinse) is a covered medication. This offer is not valid for any person eligible for reimbursement of prescriptions, in whole or in part, by any federal, state, or other governmental programs, including, but not limited to, Medicare (including Medicare Advantage and Part A, B, and D plans), Medicaid, TRICARE, Veterans Administration or Department of Defense health coverage, CHAMPUS, the Puerto Rico Government Health Insurance Plan, or any other federal or state health care programs. You agree not to seek reimbursement for all or any part of the benefit received through this offer and are responsible for making any required reports of your use of this offer to any insurer or other third party who pays any part of the prescription filled. This offer is good only in the United States of America (including the District of Columbia, Puerto Rico and the U.S. Virgin Islands) This offer is not valid where otherwise prohibited, taxed, or otherwise restricted. This offer is not valid for any person that is 65 years of age or older without commercial insurance. You must be 18 years of age or older to redeem this offer for yourself or a minor. This offer cannot be redeemed at government-subsidized clinics. This offer is valid for one (1) initial prescription fill of NeutraSal® and up to ten (10) prescription refills. The maximum benefit available is $1,500. You are responsible for all costs and expenses after the maximum benefit is reached. If you receive coverage through a health savings account (HSA) or similar arrangement, it is your responsibility to know how claims are processed and understand that amounts paid by the third party for your NeutraSal® prescription may be deducted from your benefits limit automatically. This offer is not valid with other offers. The coupon has no cash value. No cash back. This offer is not health insurance. This offer expires on December 31, 2018. Valeant Pharmaceuticals and OraPharma reserve the right to rescind, revoke, terminate, or amend this offer at any time, without notice.

 

Copyright © 2018, Valeant Pharmaceuticals North America LLC    NSL.0041.USA.18

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INDICATIONS

NeutraSal® is indicated for dryness of the mouth (hyposalivation, xerostomia) and dryness of the oral mucosa due to drugs that suppress salivary secretion.

IMPORTANT SAFETY INFORMATION
  • Not intended to prevent xerostomia or oral mucositis.
  • Patients should avoid eating or drinking for at least 15 minutes after use
  • Solution should not be swallowed but be spit out.
  • Not intended for systemic use to treat any diseases of the throat or upper gastrointestinal tract
  • Not intended for use as an antacid
  • No adverse events anticipated if swallowed accidentally
  • Contains sodium; consult with patients on a low sodium diet
  • No known interactions with medicinal or other products

Please click here for Instructions for Use.