NeutraSal is indicated for:

• Dryness of the mouth (hyposalivation, xerostomia)
• Dryness of the oral mucosa due to drugs such as antihistamines or atropine or other anticholinergic agents that suppress salivary secretion
• Use as part of an oral hygiene program for patients with dry mouth
• Providing intensive hygiene of the oral cavity
• Use as an adjunct to standard oral care in relieving the discomfort associated with oral mucositis that may be caused by radiation or high-dose chemotherapy
• Relief of dryness of the oral mucosa in these conditions is associated with amelioration of pain

NeutraSal may be used for relief of dryness of the oral mucosa when hyposalivation results from the following:

• Surgery
• Chemotherapy
• Radiotherapy near the salivary glands
• Infection or dysfunction of the salivary glands
• Obstruction of the salivary ducts
• Fever
• Emotional factors such as fear or anxiety
• Sjögren's syndrome

(Active) Dibasic Sodium Phosphate, Monobasic Sodium Phosphate, Calcium Glycerophosphate, Sodium Chloride, Sodium Bicarbonate (Inactive) Silicon dioxide

NeutraSal has no wheat, nuts, eggs, gluten, yeast, milk, soy, shellfish, or preservative ingredients.

NeutraSal has an established safety profile:

• Not intended to prevent xerostomia or oral mucositis.
• Patients should avoid eating or drinking for at least 15 minutes after use
• Solution should not be swallowed but be spit out.
• Not intended for systemic use to treat any diseases of the throat or upper gastrointestinal tract
• Not intended for use as an antacid
• No adverse events anticipated if swallowed accidentally
• Contains sodium; Patients restricted to a low-sodium diet should consult their physician before use
• No known interactions with medicinal or other products

Please click here for Instructions for Use.

Dissolve or disperse 1 packet of NeutraSal in a clean glass of approximately 30 mL (1 ounce) of tap water. Distilled or purified water can also be used. Use immediately after the solution appears clear or nearly clear in the glass, or in about 15 seconds. Product can be stirred in water.

(1) Swish the solution in the mouth thoroughly for 1 minute with ½ of the solution and spit out.

(2) Repeat with the remaining ½ of the solution and spit out.

For relief of dry mouth: Use as an oral rinse 2 to 10 times per day for the duration of the treatment as instructed by the physician or as needed.

For use during high-dose chemotherapy or radiation treatment: 4 doses per day from the onset of the cancer treatment as instructed by the physician or as needed. Up to 10 doses per day may be used if pain or symptoms from mucositis are experienced.

NeutraSal must be diluted in 1 ounce of water to achieve the full clinical benefit.

NeutraSal has a slightly salty taste; however, it is well tolerated by patients.

The present formulation can provide higher concentrations of calcium and phosphate, a difference made possible by providing a stable powder to be mixed with water, in contrast to commercially available liquid products. The delivery through a powder allows for the creation of an oral rinse that achieves statistically significantly higher levels of calcium and phosphate than can otherwise be achieved when delivered in liquid containing calcium and phosphate.¹ NeutraSal is a supersaturated solution of calcium phosphate.

NeutraSal should be used within 15 seconds after mixing to achieve the full clinical benefit. After this time period, the supersaturation benefit of the calcium phosphate ions will decrease. Calcium phosphate dissolves in water to form a supersaturated solution, but the supersaturated solution is not stable and calcium phosphate could precipitate out if the supersaturated solution sits for a long time. Multiple factors, such as changing temperature, increasing pressure, etc, could cause precipitation from a supersaturated solution.

It is an advanced electrolyte solution that mimics natural saliva and contains electrolytes such as calcium, phosphate, sodium, bicarbonate, and chloride, which are necessary for a healthy, functioning mouth. NeutraSal is designed to replace the normal ionic and pH balance in the mouth.

When NeutraSal is taken, ions in the the mouth such as calcium and phosphate play crucial roles in the protection process and aid in mineralization. Bicarbonate reduces the acidity (raises pH) of oral fluids.

No, NeutraSal mimics natural saliva and helps alleviate symptoms of xerostomia and oral mucositis while helping to protect oral mucosal tissues. Please see your dentist or healthcare professional for more information.

NeutraSal is not indicated as an anticavity rinse. It is indicated for the treatment of xerostomia and oral mucositis. However, by mimicking saliva, the calcium and phosphate help mineralize enamel and the bicarbonate raises the pH of the oral cavity.

Yes, patients should refrain from eating and drinking for 15 minutes after rinsing with NeutraSal

A prescription should be dispensed at the time of diagnosis of xerostomia. Xerostomia can result from many medical conditions such as diabetes and Sjögren's Syndrome, as well as other autoimmune diseases, just to name a few. It can also be a side effect of over 400 medications, such as diuretics, anti-Parkinson medications, and antidepressants.

A prescription should be submitted in advance so the patient receives it before treatment begins.

There are no contraindications for use in pediatric patients, as long as these patients use NeutraSal according to the Instructions for Use, which may require adult supervision. NeutraSal is a prescription oral rinse and should be kept out of reach of children.